Mass General Brigham

The Think Engine

Part of the MGB Center for Digital Mental Health

The Think Engine's Focus

A dedicated engine for testing, building, and scaling ideas & tools that transform our understanding of cognition and behaviorTurning cognition into a vital sign

Research areas:• Digital neuropsychology
• Risk assessment
• Machine learning
• Precision diagnostics
• Brain health

Affiliation

• McLean Hospital, Massachusetts General Brigham
• Harvard Medical School Teaching Hospital
• The Center for Digital Mental HealthDr. Singh leads the Think Engine and the Digital Neuropsychology and Brain Health Lab at McLean Hospital. She is an instructor in Psychology at Harvard Medical School and a licensed clinical neuropsychologist.

The Think Suite

Comprised of a digital cognitive assessment platform to make brain health measurement accessible, scalable, and equitable. In comparison, traditional neuropsychological assessments are lengthy and rely heavily on paper. This tool brings those assessments out of the clinics and into everyday life.

A2 Project

Explores how digital technologies can enhance the assessment and monitoring of cognitive health in older adults. As rates of Alzheimer's disease and related dementias continue to rise, there is a growing need for scalable, accessible tools that can complement traditional neuropsychological evaluations.Our research integrates multiple sources of real-world data, including digital cognitive assessments, speech-based tasks, emotional self-reports, and wearable sensor, to better understand how cognitive impairment is reflected in everyday behavior.

Publications

1. Singh S, Germine L. Technology meets tradition: a hybrid model for implementing digital tools in neuropsychology. Int Rev Psychiatry. 2021 Jun;33(4):382-393. doi: 10.1080/09540261.2020.1835839. Epub 2020 Nov 25. Review. PubMed PMID: 33236657
2. Singh S, Strong RW, Jung L, Li FH, Grinspoon L, Scheuer LS, Passell EJ, Martini P, Chaytor N, Soble JR, Germine L. The TestMyBrain Digital Neuropsychology Toolkit: Development and Psychometric Characteristics. J Clin Exp Neuropsychol. 2021 Oct;43(8):786-795. doi: 10.1080/13803395.2021.2002269. Epub 2021 Dec 15. PubMed PMID: 34907842; PubMed Central PMCID: PMC8922997.
3. Singh S, Kluen L, Curtis K, Norel R, Agurto C, Grinspoon E, Hawks Z, Christ S, Waisbren S, Cecchi G, Germine L. Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population. JMIR Form Res. 2025 Jun. 3;9:e63644. doi: 10.2196/63644. PMID: 40072884; PMCID: PMC12174882
4. Singh S, Strong R, Xu I, Fonseca LM, Hawks Z, Grinspoon E, Jung L, Li F, Weinstock RS, Sliwinski MJ, Chaytor NS, Germine LT. Ecological Momentary Assessment of Cognition in Clinical and Community Samples: Reliability and Validity Study. J Med Internet Res. 2023 Jun 2;25:e45028. doi: 10.2196/45028. PubMed PMID: 37266996; PubMed Central PMCID: PMC10276323
5. Germine L, Strong RW, Singh S, Sliwinski MJ. Toward dynamic phenotypes and the scalable measurement of human behavior. Neuropsychopharmacology. 2021 Jan;46(1):209-216. doi: 10.1038/s41386-020-0757-1. Epub 2020 Jul 6. Review. PubMed PMID: 32629456; PubMed Central PMCID: PMC7689489

Dr. Shifali Singh
Principal Investigator

Nhi Huynh
Research Intern

Shadan Al Zuhairi
Research Intern

Kayleen Mukire
Research Intern

Vivien Cheng
Lead Clinical Research Coordinator

May Ng
Research Intern

Yubi Mamiya
Research Intern

Kayla Cadet
Research Intern

Get in touch: Contact us

Feel free to contact us with any questions or inquiries you may have:
The Think Engine
Digital Neuropsychology and Brain Health Lab
115 Mill St,
Belmont, MA 02478